Overview

About the Non-human Primate Neuroimaging Neuroanatomy Project

Mapping the human brain has been a grand challenge in neuroscience for over a century. Non-human primates (NHPs) have also been intensively studied using research methods not readily carried out in humans. Such studies reveal detailed aspects of brain organization, connectivity, and function, including principles that inform our understanding of the human brain.

The Non-human Primate Neuroimaging & Neuroanatomy Project (NHP-NNP) was launched in 2018. It aims to chart neural pathways that underlie brain function and behavior, using high-quality non-invasive neuroimaging data in over 100 subjects of healthy adult macaque and marmoset monkeys, plus detailed mapping of anatomical connections in macaques.

The neuroimaging techniques in the NHP-NNP conform to the Human Connectome Project (HCP)-style approach, which provides greatly improved methods for data acquisition, analysis, visualization and sharing. This enables accelerated progress in elucidating brain structure, function, and connectivity and their relationships to behavior.

Principal Investigators

Takuya Hayashi, M.D. Ph.D.

Takuya Hayashi, M.D. Ph.D.

RIKEN Center for Biosystems Dynamics Research, Kobe, JP

Henry Kennedy, Ph.D.

Henry Kennedy, Ph.D.

University Claude Bernard, Lyon, FR

Institute of Neuroscience, Shanghai, CN

David Van Essen, Ph.D.

David Van Essen, Ph.D.

Washington University in St. Louis, US

Stephen Smith, D.Phil.

Stephen Smith, D.Phil.

University of Oxford, Oxford, UK

Investigators

Toshihiko Aso, M.D., Ph.D., RIKEN BDR, Kobe, JP

Joonas Autio, Ph.D., RIKEN BDR, Kobe, JP

Takuro Ikeda, Ph.D., RIKEN BDR, Kobe, JP

Akiko Uematsu, Ph.D., RIKEN BDR, Kobe, JP

Yuki Hori, Ph.D., RIKEN BDR, Kobe, JP

Chihiro Yokoyama, Ph.D., RIKEN BDR, Kobe, JP

Miho Murayama, Ph.D., Kyoto University Wildlife Research Center, Kyoto, JP

Matthew F Glasser, M.D., Ph.D., Washington University in St. Louis, US

Timothy Coalson, Programmer, Washington University in St. Louis, US

Reid Erin, Research Technician, Washington University in St. Louis, US

John Harwell, Programmer, Washington University in St. Louis, US

Kenneth Knoblauch, Ph.D., Stem-cell and Brain Research Institute, Lyon, FR

Yujie Hou, Ph.D.student, Stem-cell and Brain Research Institute, Lyon, FR

Pierre Misery, B. Eng., Stem-cell and Brain Research Institute, Lyon, FR

Camille Lamy, B. Eng., Stem-cell and Brain Research Institute, Lyon, FR

Loic Magrou, Ph.D., New York University, US

Zhiming Shen, Ph.D., Institute of Neuroscience, Shanghai, CN

For study protocols in NHP_NNP, please go to:

HCP-NHP Protocols

Publications

  1. Markov, N.T., Ercsey-Ravasz, M.M., Ribeiro Gomes, A.R., Lamy, C., Magrou, L., Vezoli, J., Misery, P., Falchier, A., Quilodran, R., Gariel, M.A., Sallet, J., Gamanut, R., Huissoud, C., Clavagnier, S., Giroud, P., Sappey-Marinier, D., Barone, P., Dehay, C., Toroczkai, Z., Knoblauch, K., Van Essen, D.C., Kennedy, H., 2014. A weighted and directed interareal connectivity matrix for macaque cerebral cortex. Cereb. Cortex 24, 17–36. doi:10.1093/cercor/bhs270
  2. Van Essen, D.C., Donahue, C.J., Coalson, T.S., Kennedy, H., Hayashi, T., Glasser, M.F., 2019. Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice. Proc. Natl. Acad. Sci. U.S.A. 2019 116 (52) 26173-26180. doi:10.1073/pnas.1902299116
  3. PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium, 2020. Accelerating the Evolution of Nonhuman Primate Neuroimaging. Neuron 105, 600–603. doi:10.1016/j.neuron.2019.12.023
  4. Autio, J.A., Glasser, M.F., Ose, T., Donahue, C.J., Bastiani, M., Ohno, M., Kawabata, Y., Urushibata, Y., Murata, K., Nishigori, K., Yamaguchi, M., Hori, Y., Yoshida, A., Go, Y., Coalson, T.S., Jbabdi, S., Sotiropoulos, S.N., Kennedy, H., Smith, S., Van Essen, D.C., Hayashi, T., 2020. Towards HCP-Style Macaque Connectomes: 24-Channel 3T Multi-Array Coil, MRI Sequences and Preprocessing. Neuroimage 116800. doi:10.1016/j.neuroimage.2020.116800
  5. Hayashi, T., Hou, Y., Glasser, M.F., Autio, J.A., Knoblauch, K., Inoue-Murayama, M., Coalson, T., Yacoub, E., Smith, S., Kennedy, H., Van Essen, D.C., 2021. The nonhuman primate neuroimaging and neuroanatomy project. Neuroimage 229, 117726. doi:10.1016/j.neuroimage.2021.117726
  6. Autio, J.A., Zhu, Q., Li, X., Glasser, M.F., Schwiedrzik, C.M., Fair, D.A., Zimmermann, J., Yacoub, E., Menon, R.S., Van Essen, D.C., Hayashi, T., Russ, B., Vanduffel, W., 2021. Minimal specifications for non-human primate MRI: Challenges in standardizing and harmonizing data collection. NeuroImage 236, 118082. doi.org/10.1016/j.neuroimage.2021.118082
  7. Koike, S., Tanaka, S., Okada, T., Aso, T., Yamashita, A., Yamashita O., Asano, M., Maikusa, N., Morita, K., Okada, N., Fukunaga, M., Uematsu, A., Togo, H., Miyazaki, A., Murata, K., Urushibata, Y., Autio, J.A., Ose, T., Yoshiomoto, J., Araki, T., Glasser, M.F., Essen, D.C.V., Murayama, M., Sadato, N., Kawato, M., Kasai, K., Okamoto, Y., Hanakawa, T., Hayashi, T., Group BMM-HBM., 2021. Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-level Harmonization across Brain Disorders Throughout the Lifespan. NeuroImage:Clinical 102600. doi.org/10.1016/j.nicl.2021.102600